Myxedema Coma

Very rarely do we see patients presenting with the symptoms of myxedema coma. This is a life threatening condition that is caused by a deficiency in the thyroid gland causing hypothyroidism. First, let's take a look at hypothyroidism to see what symptoms lead to a patient being in a myxedema coma.

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Symptoms Of Hypothyroidism

The thyroid gland is responsible mainly for regulating a person's metabolism and use of energy including breathing, heart rate, body weight, menstrual cycles, body temperature, and more.  Having too much or too little thyroid hormone can cause major disturbances to a person's metabolism and organ function.  According to the Mayo Clinic, symptoms of hypothyroidism are as follows:

  • Fatigue

  • Increased sensitivity to cold

  • Constipation

  • Dry skin

  • Weight gain

  • Puffy face

  • Hoarseness

  • Muscle weakness

  • Elevated blood cholesterol level

  • Muscle aches, tenderness and stiffness

  • Pain, stiffness or swelling in your joints

  • Heavier than normal or irregular menstrual periods

  • Thinning hair

  • Slowed heart rate

  • Depression

  • Impaired memory

How Does Hypothyroidism Develop Into A Myxedema Coma? 

A myxedema coma can result when thyroid hormone levels are dangerously low. This can happen quickly or over a series of months. The main causes (in association with hypothyroidism) are as follows:


One patient I cared for in the ICU had a mixture of clinical symptoms which we treated.  The patient was extremely lethargic, had a very swollen face/neck, low body temperature, low blood pressure, and very abnormal thyroid hormone levels. We consulted endocrinology and there were a variety of interventions that we had to perform. We gave a very large loading dose of levothyroxine, maintenance doses of levothyroxine, and doses of iodothyronine. These help to reestablish normal levels of thyroid hormones and body metabolism. The patient was hypothermic at 93.1 degrees so we warmed him using a bair hugger blanket (essentially a blanket inflated with warm air). We gave hydrocortisone to boost his cortisol levels. We monitored his electrolytes very closely, and he received multiple doses of potassium, magnesium, calcium, and potassium phosphate. The patient's blood pressure was low so he received multiple fluid boluses and was eventually started on vasopressors for blood pressure support. This type of patient needs very close attention to vital signs and lab results. If not treated quickly enough, patients can die from this condition.

Other relevant articles include:



Web MD

Mayo Clinic

AuthorCourtney Tracy