It can be very frustrating when you go to draw blood from a PICC line and it is clotted off.  One common way to declot a PICC line is by using Alteplase (rTPA) to break up the clot.  Make sure to perform this using whatever policy is in place at your hospital.  I needed to use TPA on a PICC line recently and this is not only our hospital policy, but it seems to be the common way to instill TPA into a PICC line. 

AuthorCourtney Tracy